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KMID : 0858420090110030130
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Korean Journal of Stroke
2009 Volume.11 No. 3 p.130 ~ p.135
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Does Smoking Increase a rist of Hemorrhage Transformation in Acute Ischemic Stroke?
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Park Jung-Hyun
Ko Yong-Chai
Yang Mi-Hwa
Ko Sang-Bae
Han Moon-Ku
Lee June-Young
Bae Hee-Joon
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Abstract
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Background: Smoking is being established as a risk factor for hemorrhagic stroke. But it is not established whether smoking can increase the risk of hemorrhagic transformation (HT) in acute ischemic stroke.
Methods: From January 2004 to August 2007, cases with HT, defined as any HT detected by brain MRI or CT within 14 days from symptom onset, were identified among a consecutive series of patients hospitalized due to acute ischemic stroke within 7 days of onset. For each case with HT, 4 age and sex-matched controls were selected among patients without HT. Conditional logistic regression was used to calculate odd ratios before [crude odd ratio (OR)] and after adjustment for confounders identified from the dataset (adjusted OR1) and additional adjustment for factors reported to increase the risk of HT from literatures (adjusted OR2).
Results: One-hundred thirty five cases (mean age of 68 years) and 540 controls were recruited in this study. The proportion of current smoker were 23.7% (n=32) in cases and 26.3% (n=142) in controls (P=0.53 on pearson Chi-square test). Adjusted OR1 was 1.32 (95% confidence interval, 0.76 to 2.29) and adjusted OR2 was 1.28 (0.73 to 2.25). Not only the analysis confining to cases with symptomatic HT and their matched controls but also stratified analysis according to thrombolysis did not reveal the significant association between smoking status and hemorrhage transformation.
Conclusions: Our study suggests that smoking does not increase the risk of hemorrhagic transformation after acute ischemic stroke.
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KEYWORD
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Cerebral infarction, Smoking, Hemorrhagic transformation,
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